Vectorology - GEG Tech top picks

Disease-inducible promoters for the treatment of rheumatoid arthritis (RA) have the potential to provide regulated expression of therapeutic proteins in arthritic joints. Here, the authors design an inducible lentiviral CXCL10p-IL10. Their results show that CXCL10 promoter activation is strongest at 8-12h after stimulation with the pro-inflammatory cytokine TNFα and is re-inducible after 96h. In addition, the CXCL10 promoter showed a significant response to RA patient serum, compared to serum from healthy individuals. In conclusion CXCL10 promoter-regulated IL-10 overexpression could provide disease-inducible local gene therapy suitable for RA.

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