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Vectorology - GEG Tech top picks
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In order to develop novel strategies to genetically manipulate T-ALL leukaemia-initiating cells (LIC), the scientists examined whether primary TALL cells express the receptors for different lentiviral vector pseudotyping glycoproteins, such as the vesicular-stomatitis-virus G protein (VSVG) (4), the measles virus hemagglutinin (H) and fusion (F) glycoproteins (5) and the baboon retroviral envelope glycoprotein (BaEV) (6). In summary, they find that BaEV-pseudotyped LVs have an exceptional capacity to transduce T-ALL LICs without altering their self-renewing properties.