Vectorology - GEG Tech top picks

In this study, the scientists used a lentiviral vector which express shRNA  Notch1, known as a cell fate regulator, to investigate its role in the mechanism of endometriosis. The results showed that LV-Notch1-shRNA led to a significant decline of clonogenicity and migration in human endometrial stem cells in vitro, as well as the size of endometriotic lesions in murine models. These data provide evidence that specific inhibition of Notch1 alters endometriotic tissue growth and progression, and may represent a promising potential therapeutic avenue.