In this study, the authors used lentiviral vectors miR-101 and anti-miR-101 to invectigate miR-101's role in regulation of ABCA1 and cholesterol. They show that miR-101 promotes intracellular cholesterol retention under inflammatory conditions through suppressing ABCA1 expression and suggests that the miR-101-ABCA1 axis may play an intermediary role in the development of NAFLD and vascular atherosclerosis.
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In this study, the authors used lentiviral vectors miR-101 and anti-miR-101 to invectigate miR-101's role in regulation of ABCA1 and cholesterol. They show that miR-101 promotes intracellular cholesterol retention under inflammatory conditions through suppressing ABCA1 expression and suggests that the miR-101-ABCA1 axis may play an intermediary role in the development of NAFLD and vascular atherosclerosis.
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