Vectorology - GEG Tech top picks

Here the authors used a lentiviral vector which overexpresses integrin B1 to transduce endothelial cells. These cells are injecrted into mice which have femorla arteries occluded.

Four weeks later, blood perfusion of the ischemic limb was significantly augmented. Intravenous administration of ECFCs engineered to home to ischemic tissue appears to efficiently mediate therapeutic angiogenesis in a mouse model of peripheral artery disease.

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