Vectorology - GEG Tech top picks

Transplantation-based replacement of lost and/or dysfunctional astrocytes is a promising therapy for spinal cord injury. In this study, the authors constitutively express  the major glutamate transporter (GLT1) in human iPS cell-derived astrocytes (hIPSAs ) thanks to a lentiviral vector. They observe that GLT1 overexpressing hIPSAs reduced (1) lesion size within the injured cervical spinal cord, (2) morphological denervation by respiratory phrenic motor neurons at the diaphragm neuromuscular junction, and (3) functional diaphragm denervation as measured by recording of spontaneous EMGs and evoked compound muscle action potentials.

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