Vectorology - GEG Tech top picks

The authors used a LentiCRISPR-sgTRF2-1 to knockdown TERF2. They observe an  exacerbation of mitotic telomere deprotection which increases the ratio of cells that died during mitotic arrest and sensitized cancer cells to mitotic poisons. They propose a crisis pathway wherein chromosome fusions induce mitotic arrest, resulting in mitotic telomere deprotection and cell death, thereby eliminating precancerous cells from the population.

www.geg-tech.com/Vectors