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Vectorology - GEG Tech top picks
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To mimic the downregulation or upregulation of TNIP1, the authors used lentiviral vectors (TNIP1 shRNA or rTNIP1). Intradermal injection of TNIP1 shRNA in BALB/c mice led to exaggerated psoriatic conditions in imiquimod (IMQ)-induced psoriasis-like dermatitis. These findings indicate that TNIP1 has a protective role in psoriasis and therefore could be a promising therapeutic target.
www.geg-tech.com/Vectors