Employing a murine model of retinal disease, the scientists demonstrate that ciliary neurotrophic factor (CNTF) confers life-long protection against photoreceptor degeneration. The mechanisms underlying CNTF-mediated neuroprotection were explored through transcriptome analysis, revealing widespread up-regulation of proteolysis inhibitors, which may prevent cellular/extracellular matrix degradation and complement activation in neurodegenerative diseases.
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Employing a murine model of retinal disease, the scientists demonstrate that ciliary neurotrophic factor (CNTF) confers life-long protection against photoreceptor degeneration. The mechanisms underlying CNTF-mediated neuroprotection were explored through transcriptome analysis, revealing widespread up-regulation of proteolysis inhibitors, which may prevent cellular/extracellular matrix degradation and complement activation in neurodegenerative diseases.
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