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Vectorology - GEG Tech top picks
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In this study, the authors knock down with a shRNA lentiviral vector the methyl CpG binding protein 2 (MeCP2) which enhances NF-κB activation in human peripheral blood mononuclear cells. They observed that MeCP2 deficiency increases expression of TNFα and other inflammatory cytokines by enhancing NF-κB signaling. 
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In this study, the authors design a strategy based on the use of two lentiviral vectors and the CRE/Lop system to easily generate kidney cell-specific knockdown mice. This method might be open to other species.
www.geg-tech/Vecors