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Despite lentiviral system’s predominance, its ultimate potential for gene therapy has not been fully exploited. Currently, most lentivirus vectors are non-inducible expression system or single-gene-in 
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BigField GEG Tech's insight:
The authors tested whether viral-mediated overexpression of HSP70 can protect hair cells (HCs) and hearing from severe ototoxicity (kanamycin and furosemide) in guinea pigs. Adenovirus-HSP70 mCherry (Ad.HSP70-mCherry) was injected to experimental animals and exhibited a significant preservation of inner HCs but outer HCs were not protected.The authors think that HSP70 augmentation may represent a potential therapy attenuating ototoxic inner HC loss.
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In this study, the scientist designed a novel lentiviral vector containing HSP70 promoter and TRE promoter. Compared to traditional lentiviral vectors and inducible vectors, this controllable system has many advantages.