Vectorology - GEG Tech top picks

Non-integrating lentiviral vectors or also known as integrase-defective lentiviral (IDLV) hold a great promise for gene therapy application. Here the scientists describe the system of IDLV which is produced through mutation in the integrase enzymes at the position of D64 located within the catalytic core domain. They show that the percentage of GFP-positive cells decreased from ~50 % to almost 0, up to 10 days post-transduction. They conclude that integrase-defective lentivirus will be a suitable choice for safer clinical applications. It preserves the advantages of the wild-type lentiviral vectors but with the benefit of transgene expression without stable integration into host genome, therefore reducing the potential risk of insertional mutagenesis.

GEG Tech provides a large range of IDLVs and also several lines of this type of vector with different intergase mutations (including D64V). 

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